Abstract
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the world. Vitamin E as an anti-oxidant vitamin, was suggested to have a role in the prevention of CVD. We did a meta-analysis, using the Cochrane Group Methodology, of all available randomized controlled trials (RCTs) to evaluate the role of vitamin E in the prevention of CVD. Nine studies met inclusion criteria, including 80,645 participants. Vitamin E supplementation was not associated with a reduction in total mortality or total CVD mortality, but it was associated with a small statistically significant reduction in non-fatal myocardial infarction in patients with pre-existing coronary artery disease. Prophylactic use of vitamin E in doses ranging between 50-800 IU was not associated with any increase in the incidence of serious side effects.
Article Type
Review
First Page
23
Last Page
29
Recommended Citation
Alkhenizan, Abdullah H. and Al-Omran, Mohammed A.
(2005)
"The role of vitamin E in the prevention of coronary events and stroke. Meta-analysis of randomized controlled trials,"
Neurosciences Journal: Vol. 10:
Iss.
1, Article 4.
DOI: 10.17712/1658-3183.1306
Available at:
https://nsj.researchcommons.org/journal/vol10/iss1/4
DOI
10.17712/1658-3183.1306