Abstract
Drug-induced Parkinsonism must always be suspected when parkinsonian symptom like rigidity, tremor, or postural instability appear in patients receiving drug treatment. Indeed, drug-induced Parkinsonism is a frequent etiology of secondary Parkinsonism. The main causative drugs are antipsychotic, other neuroleptic drugs, and calcium-channel entry blockers. The risk associated with antipsychotics is often dose dependent and related to dopamine D2 striatal occupancy. The risk is less for the second-generation atypical antipsychotic. The other treatments rarely involved are antidepressants, antivirals, anti-arrhythmics, lithium, valproic acid, and others. Regression of symptom will be observed in most cases after a mean delay of 3 months after cessation of treatment. In one-tenth of cases, symptoms persist after drug withdrawal leading to the diagnosis of underlined idiopathic Parkinson9s disease.
Article Type
Review
First Page
215
Last Page
221
Recommended Citation
Bohlega, Saeed A. and Al-Foghom, Nurah B.
(2013)
"Drug-induced Parkinson's disease. A clinical review,"
Neurosciences: Vol. 18:
Iss.
3, Article 1.
DOI: https://doi.org/10.17712/1658-3183.2020