Abstract
Objective: To compare cerebrospinal fluid visinin-like protein-1 (CSF VLP-1) in alzheimer’s disease (AD) with that in healthy controls and mild cognitive impairment (MCI) patients and find out possible sources of heterogeneity. Method: “Visinin-like protein-1” and “alzheimer’s disease” were employed to search “PubMed”, “Springer” and “Medline” databases until July 2016 and standard mean difference (Std.MD) was calculated. Besides, subgroup analysis and meta-regression were performed to explore the possible heterogeneity sources. Results: Seven studies involved 1151 participants were pooled. The CSF VLP-1 in AD patients was higher than that in healthy controls and MCI patients (pooled Std.MD=0.81, 95% CI: [0.47, 1.16], p <0.00001). As shown by subgroup analysis, population variations were one of heterogeneity sources. Meta-regression revealed that Hedges’s g of CSF VLP-1 was correlated with Std.MD of t-tau (r=0.560, p =0.006) and Ab42 (r=-0.386, p =0.013). Conclusion: The CSF VLP-1 in AD patients is higher than that in healthy controls and MCI patients. The changes of VLP-1 in AD patients relative to healthy controls and MCI patients is less pronounced than that of core biomarkers, such as Ab42, t-tau and p-tau. Population variations, increasing t-tau and decreasing Ab42 in AD patients relative to healthy controls and MCI patients were the main sources of heterogeneity.
Article Type
Review
First Page
94
Last Page
101
Recommended Citation
Hu, Xiaohui; Yang, Yan; and Gong, Daokai
(2017)
"A meta-analysis of cerebrospinal fluid visinin-like protein-1 in alzheimer’s disease patients relative to healthy controls and mild cognitive impairment patients,"
Neurosciences: Vol. 22:
Iss.
2, Article 2.
DOI: https://doi.org/10.17712/nsj.2017.2.20160557