Abstract
Objectives: To compare the efficacy and safety of corpus callosotomy versus vagus nerve stimulation (VNS) as long-term adjunctive therapies in children with Lennox–Gastaut syndrome. Methods: This retrospective study was conducted in King Fahad Medical City between 2010 and 2019. The authors identified and followed 9 patients with Lennox–Gastaut syndrome (LGS) who underwent corpus callosotomy or VNS implantation for at least 12 months; seizure frequency and major complications were monitored. Five patients with a mean age of 10.8±1.3 years had corpus callosotomy, and 4 patients with a mean age of 13.8±3.9 years were implanted with VNS stimulators. Results: Reduction in seizure frequency was achieved in all 5 patients who underwent corpus callosotomy, with greater than 75% seizure reduction in more than 50% in one, and greater than 25% in 2 respectively. However, in those implanted with VNS, 2 (50%) patients achieved a reduction in seizure frequency of greater than 75% and 2 (50%) greater than 25%, respectively. No significant difference was observed between the 2 treatment groups. One patient who underwent corpus callosotomy suffered cerebrospinal fluid leakage, and swallowing difficulties in one patient who underwent VNS. Conclusion: Both corpus callosotomy and VNS are safe and effective as adjunctive treatments for LGS patients.
Article Type
Research Article
First Page
59
Last Page
64
Recommended Citation
Alanazi, Ghalib M.; ALOsaimi, Turki F.; Alwadei, Ali H.; Al-Otaibi, Ali D.; Jad, Lamya A.; and Al-Attas, Alawi A.
(2022)
"Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox–Gastaut syndrome: Experience of a tertiary care center,"
Neurosciences: Vol. 27:
Iss.
2, Article 1.
DOI: https://doi.org/10.17712/nsj.2022.2.20210135